Venue: Boston Convention and Exhibition Center
Date:?Jul 26, 2023?-?Jul 28, 2023
The mRNA Based Therapeutics Summit, the important, authoritative, and comprehensive premier forum, will hold its third session in Boston in July this year. Many experts and company executives in the industry will attend to introduce the latest developments in mRNA pipelines, share mRNA technology breakthroughs, and demonstrate mRNA-related products.
Featured Presentation
Date:?July 27, 2023
Time:?2:30 p.m. Eastern Time
Title:?Development of Novel Trinucleotide Cap Analogs LZCap?(3’-Acm7mG) for Highly Efficient ‘One-Pot’ mRNA IVT Preparation
Featured Speaker:
Larry (Jiancun) Zhang
Founder & Chairman, Guangzhou Henovcom Biosciences Co., Ltd.
Key points:
-A novel trinucleotide cap analogue suitable for the one-pot in vitro-transcription (IVT) process with high yield and high capping rate of Cap1 mRNA
- Compared to mRNAs with 3’-OMe7mG, mRNAs with LZCap? (3’-Acm7mG) demonstrate significantly higher protein expression both in vitro and in vivo
- Compared to mRNAs with 3 '- OMe7mG, mRNAs with LZCap? (3' - Acm7mG) exhibits better stability against Dcp2 decapping enzyme and higher eIF4E binding affinity, while exhibiting comparably low immunogenicity and safety profile
- mRNAs with LZCap? labeled with fluorescence, including biotin, FAM, Cy3 and Cy5, could be directly obtained through the one-pot IVT process, and could facilitate the screening of delivery vehicles and formulations
